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Modifications to the Hemagglutinin Cleavage Site Control the Virulence of a Neurotropic H1N1 Influenza Virus

A key determinant of influenza virus pathogenesis is mutation in the proteolytic cleavage site of the hemagglutinin (HA). Typically, low-pathogenicity forms of influenza virus are cleaved by trypsin-like proteases, whereas highly pathogenic forms are cleaved by different proteases (e.g., furin). Inf...

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Detalhes bibliográficos
Main Authors: Sun, Xiangjie, Tse, Longping V., Ferguson, A Damon, Whittaker, Gary R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2919019/
https://ncbi.nlm.nih.gov/pubmed/20554779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00797-10
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