Role of Position 627 of PB2 and the Multibasic Cleavage Site of the Hemagglutinin in the Virulence of H5N1 Avian Influenza Virus in Chickens and Ducks

Highly pathogenic H5N1 avian influenza viruses have caused major disease outbreaks in domestic and free-living birds with transmission to humans resulting in 59% mortality amongst 564 cases. The mutation of the amino acid at position 627 of the viral polymerase basic-2 protein (PB2) from glutamic ac...

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Main Authors: Schat, Karel A., Bingham, John, Butler, Jeff M., Chen, Li-Mei, Lowther, Sue, Crowley, Tamsyn M., Moore, Robert J., Donis, Ruben O., Lowenthal, John W.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2012
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3283584/
https://ncbi.nlm.nih.gov/pubmed/22363523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0030960
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