Insertion of a Multibasic Cleavage Motif into the Hemagglutinin of a Low-Pathogenic Avian Influenza H6N1 Virus Induces a Highly Pathogenic Phenotype

The highly pathogenic avian influenza (HPAI) virus phenotype is restricted to influenza A viruses of the H5 and H7 hemagglutinin (HA) subtypes. To obtain more information on the apparent subtype-specific nature of the HPAI virus phenotype, a low-pathogenic avian influenza (LPAI) H6N1 virus was gener...

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Detalhes bibliográficos
Main Authors: Munster, Vincent J., Schrauwen, Eefje J. A., de Wit, Emmie, van den Brand, Judith M. A., Bestebroer, Theo M., Herfst, Sander, Rimmelzwaan, Guus F., Osterhaus, Albert D. M. E., Fouchier, Ron A. M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2010
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2916526/
https://ncbi.nlm.nih.gov/pubmed/20519405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00449-10
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