Insertion of a Multibasic Cleavage Motif into the Hemagglutinin of a Low-Pathogenic Avian Influenza H6N1 Virus Induces a Highly Pathogenic Phenotype

The highly pathogenic avian influenza (HPAI) virus phenotype is restricted to influenza A viruses of the H5 and H7 hemagglutinin (HA) subtypes. To obtain more information on the apparent subtype-specific nature of the HPAI virus phenotype, a low-pathogenic avian influenza (LPAI) H6N1 virus was gener...

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Bibliografiset tiedot
Päätekijät: Munster, Vincent J., Schrauwen, Eefje J. A., de Wit, Emmie, van den Brand, Judith M. A., Bestebroer, Theo M., Herfst, Sander, Rimmelzwaan, Guus F., Osterhaus, Albert D. M. E., Fouchier, Ron A. M.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Microbiology (ASM) 2010
Aiheet:
Pathogenesis and Immunity
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2916526/
https://ncbi.nlm.nih.gov/pubmed/20519405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00449-10
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