Insertion of a Multibasic Cleavage Motif into the Hemagglutinin of a Low-Pathogenic Avian Influenza H6N1 Virus Induces a Highly Pathogenic Phenotype

The highly pathogenic avian influenza (HPAI) virus phenotype is restricted to influenza A viruses of the H5 and H7 hemagglutinin (HA) subtypes. To obtain more information on the apparent subtype-specific nature of the HPAI virus phenotype, a low-pathogenic avian influenza (LPAI) H6N1 virus was gener...

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Bibliographic Details
Main Authors: Munster, Vincent J., Schrauwen, Eefje J. A., de Wit, Emmie, van den Brand, Judith M. A., Bestebroer, Theo M., Herfst, Sander, Rimmelzwaan, Guus F., Osterhaus, Albert D. M. E., Fouchier, Ron A. M.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2010
Subjects:
Pathogenesis and Immunity
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2916526/
https://ncbi.nlm.nih.gov/pubmed/20519405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00449-10
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