Insertion of a multibasic cleavage site in the haemagglutinin of human influenza H3N2 virus does not increase pathogenicity in ferrets

A multibasic cleavage site (MBCS) in the haemagglutinin (HA) protein of influenza A virus is a key determinant of pathogenicity in chickens, and distinguishes highly pathogenic avian influenza (HPAI) viruses from low pathogenic avian influenza viruses (LPAI). An MBCS has only been detected in viruse...

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Main Authors: Schrauwen, Eefje J. A., Bestebroer, Theo M., Munster, Vincent J., de Wit, Emmie, Herfst, Sander, Rimmelzwaan, Guus F., Osterhaus, Albert D. M. E., Fouchier, Ron A. M.
Formato: Artigo
Idioma:Inglês
Publicado: Society for General Microbiology 2011
Assuntos:
Animal
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3168280/
https://ncbi.nlm.nih.gov/pubmed/21346026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1099/vir.0.030379-0
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