The Multibasic Cleavage Site in H5N1 Virus Is Critical for Systemic Spread along the Olfactory and Hematogenous Routes in Ferrets

The route by which highly pathogenic avian influenza (HPAI) H5N1 virus spreads systemically, including the central nervous system (CNS), is largely unknown in mammals. Especially, the olfactory route, which could be a route of entry into the CNS, has not been studied in detail. Although the multibas...

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Hauptverfasser: Schrauwen, Eefje J. A., Herfst, Sander, Leijten, Lonneke M., van Run, Peter, Bestebroer, Theo M., Linster, Martin, Bodewes, Rogier, Kreijtz, Joost H. C. M., Rimmelzwaan, Guus F., Osterhaus, Albert D. M. E., Fouchier, Ron A. M., Kuiken, Thijs, van Riel, Debby
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2012
Schlagworte:
Pathogenesis and Immunity
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3302532/
https://ncbi.nlm.nih.gov/pubmed/22278228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.06828-11
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