The Multibasic Cleavage Site in H5N1 Virus Is Critical for Systemic Spread along the Olfactory and Hematogenous Routes in Ferrets

The route by which highly pathogenic avian influenza (HPAI) H5N1 virus spreads systemically, including the central nervous system (CNS), is largely unknown in mammals. Especially, the olfactory route, which could be a route of entry into the CNS, has not been studied in detail. Although the multibas...

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محفوظ في:
التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Schrauwen, Eefje J. A., Herfst, Sander, Leijten, Lonneke M., van Run, Peter, Bestebroer, Theo M., Linster, Martin, Bodewes, Rogier, Kreijtz, Joost H. C. M., Rimmelzwaan, Guus F., Osterhaus, Albert D. M. E., Fouchier, Ron A. M., Kuiken, Thijs, van Riel, Debby
التنسيق: Artigo
اللغة:Inglês
منشور في: American Society for Microbiology 2012
الموضوعات:
Pathogenesis and Immunity
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC3302532/
https://ncbi.nlm.nih.gov/pubmed/22278228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.06828-11
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