The Multibasic Cleavage Site in H5N1 Virus Is Critical for Systemic Spread along the Olfactory and Hematogenous Routes in Ferrets

The route by which highly pathogenic avian influenza (HPAI) H5N1 virus spreads systemically, including the central nervous system (CNS), is largely unknown in mammals. Especially, the olfactory route, which could be a route of entry into the CNS, has not been studied in detail. Although the multibas...

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Autori principali: Schrauwen, Eefje J. A., Herfst, Sander, Leijten, Lonneke M., van Run, Peter, Bestebroer, Theo M., Linster, Martin, Bodewes, Rogier, Kreijtz, Joost H. C. M., Rimmelzwaan, Guus F., Osterhaus, Albert D. M. E., Fouchier, Ron A. M., Kuiken, Thijs, van Riel, Debby
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2012
Soggetti:
Pathogenesis and Immunity
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3302532/
https://ncbi.nlm.nih.gov/pubmed/22278228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.06828-11
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