Enhanced protective efficacy of H5 subtype influenza vaccine with modification of the multibasic cleavage site of hemagglutinin in retroviral pseudotypes

Traditionally, the multibasic cleavage site (MBCS) of surface protein H5-hemagglutinin (HA) is converted to a monobasic one so as to weaken the virulence of recombinant H5N1 influenza viruses and to produce inactivated and live attenuated vaccines. Whether such modification benefits new candidate va...

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Detalhes bibliográficos
Publicado no:Virol Sin
Main Authors: Tao, Ling, Chen, JianJun, Meng, Jin, Chen, Yao, Li, Hongxia, Liu, Yan, Zheng, Zhenhua, Wang, Hanzhong
Formato: Artigo
Idioma:Inglês
Publicado em: SP Wuhan Institute of Virology, CAS 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7091038/
https://ncbi.nlm.nih.gov/pubmed/23728771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12250-013-3326-5
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