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Low rates of mutation in clinical grade human pluripotent stem cells under different culture conditions

The occurrence of repetitive genomic changes that provide a selective growth advantage in pluripotent stem cells is of concern for their clinical application. However, the effect of different culture conditions on the underlying mutation rate is unknown. Here we show that the mutation rate in two hu...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Nat Commun
Main Authors: Thompson, Oliver, von Meyenn, Ferdinand, Hewitt, Zoe, Alexander, John, Wood, Andrew, Weightman, Richard, Gregory, Sian, Krueger, Felix, Andrews, Simon, Barbaric, Ivana, Gokhale, Paul J., Moore, Harry D., Reik, Wolf, Milo, Marta, Nik-Zainal, Serena, Yusa, Kosuke, Andrews, Peter W.
פורמט: Artigo
שפה:Inglês
יצא לאור: Nature Publishing Group UK 2020
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC7089967/
https://ncbi.nlm.nih.gov/pubmed/32251294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-15271-3
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