Mutational History of a Human Cell Lineage from Somatic to Induced Pluripotent Stem Cells

The accuracy of replicating the genetic code is fundamental. DNA repair mechanisms protect the fidelity of the genome ensuring a low error rate between generations. This sustains the similarity of individuals whilst providing a repertoire of variants for evolution. The mutation rate in the human gen...

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Detalhes bibliográficos
Publicado no:PLoS Genet
Main Authors: Rouhani, Foad J., Nik-Zainal, Serena, Wuster, Arthur, Li, Yilong, Conte, Nathalie, Koike-Yusa, Hiroko, Kumasaka, Natsuhiko, Vallier, Ludovic, Yusa, Kosuke, Bradley, Allan
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4824386/
https://ncbi.nlm.nih.gov/pubmed/27054363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1005932
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