Epigenetic resetting of human pluripotency

Much attention has focussed on the conversion of human pluripotent stem cells (PSCs) to a more naïve developmental status. Here we provide a method for resetting via transient histone deacetylase inhibition. The protocol is effective across multiple PSC lines and can proceed without karyotype change...

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Bibliographic Details
Published in:Development
Main Authors: Guo, Ge, von Meyenn, Ferdinand, Rostovskaya, Maria, Clarke, James, Dietmann, Sabine, Baker, Duncan, Sahakyan, Anna, Myers, Samuel, Bertone, Paul, Reik, Wolf, Plath, Kathrin, Smith, Austin
Format: Artigo
Language:Inglês
Published: The Company of Biologists Ltd 2017
Subjects:
Stem Cells and Regeneration
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5560041/
https://ncbi.nlm.nih.gov/pubmed/28765214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.146811
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