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Reprogramming to pluripotency: stepwise resetting of the epigenetic landscape
In 2006, the “wall came down” that limited the experimental conversion of differentiated cells into the pluripotent state. In a landmark report, Shinya Yamanaka's group described that a handful of transcription factors (Oct4, Sox2, Klf4 and c-Myc) can convert a differentiated cell back to pluri...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
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Nature Publishing Group
2011
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| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3193418/ https://ncbi.nlm.nih.gov/pubmed/21321600 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2011.28 |
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