Resetting Transcription Factor Control Circuitry toward Ground-State Pluripotency in Human

Current human pluripotent stem cells lack the transcription factor circuitry that governs the ground state of mouse embryonic stem cells (ESC). Here, we report that short-term expression of two components, NANOG and KLF2, is sufficient to ignite other elements of the network and reset the human plur...

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Detalhes bibliográficos
Main Authors: Takashima, Yasuhiro, Guo, Ge, Loos, Remco, Nichols, Jennifer, Ficz, Gabriella, Krueger, Felix, Oxley, David, Santos, Fatima, Clarke, James, Mansfield, William, Reik, Wolf, Bertone, Paul, Smith, Austin
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4162745/
https://ncbi.nlm.nih.gov/pubmed/25215486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2014.08.029
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