Nucleosides Rescue Replication-Mediated Genome Instability of Human Pluripotent Stem Cells

Human pluripotent stem cells (PSCs) are subject to the appearance of recurrent genetic variants on prolonged culture. We have now found that, compared with isogenic differentiated cells, PSCs exhibit evidence of considerably more DNA damage during the S phase of the cell cycle, apparently as a conse...

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Detalhes bibliográficos
Publicado no:Stem Cell Reports
Main Authors: Halliwell, Jason A., Frith, Thomas J.R., Laing, Owen, Price, Christopher J., Bower, Oliver J., Stavish, Dylan, Gokhale, Paul J., Hewitt, Zoe, El-Khamisy, Sherif F., Barbaric, Ivana, Andrews, Peter W.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2020
Assuntos:
Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7355123/
https://ncbi.nlm.nih.gov/pubmed/32413278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2020.04.004
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