Identification and Single-Cell Functional Characterization of an Endodermally Biased Pluripotent Substate in Human Embryonic Stem Cells

Human embryonic stem cells (hESCs) display substantial heterogeneity in gene expression, implying the existence of discrete substates within the stem cell compartment. To determine whether these substates impact fate decisions of hESCs we used a GFP reporter line to investigate the properties of fra...

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Gepubliceerd in:Stem Cell Reports
Hoofdauteurs: Allison, Thomas F., Smith, Andrew J.H., Anastassiadis, Konstantinos, Sloane-Stanley, Jackie, Biga, Veronica, Stavish, Dylan, Hackland, James, Sabri, Shan, Langerman, Justin, Jones, Mark, Plath, Kathrin, Coca, Daniel, Barbaric, Ivana, Gokhale, Paul, Andrews, Peter W.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Elsevier 2018
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5993559/
https://ncbi.nlm.nih.gov/pubmed/29779895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2018.04.015
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