Differential role of planar cell polarity gene Vangl2 in embryonic and adult mammalian kidneys

Planar cell polarity (PCP) pathway is crucial for tissue morphogenesis. Mutations in PCP genes cause multi-organ anomalies including dysplastic kidneys. Defective PCP signaling was postulated to contribute to cystogenesis in polycystic kidney disease. This work was undertaken to elucidate the role o...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Derish, Ida, Lee, Jeremy K. H., Wong-King-Cheong, Melanie, Babayeva, Sima, Caplan, Jillian, Leung, Vicki, Shahinian, Chloe, Gravel, Michel, Deans, Michael R., Gros, Philippe, Torban, Elena
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2020
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7089571/
https://ncbi.nlm.nih.gov/pubmed/32203543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0230586
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