The Planar Polarity Component VANGL2 Is a Key Regulator of Mechanosignaling

VANGL2 is a component of the planar cell polarity (PCP) pathway, which regulates tissue polarity and patterning. The Vangl2(Lp) mutation causes lung branching defects due to dysfunctional actomyosin-driven morphogenesis. Since the actomyosin network regulates cell mechanics, we speculated that mecha...

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Detalhes bibliográficos
Publicado no:Front Cell Dev Biol
Main Authors: Cheong, Sek-Shir, Akram, Khondoker M., Matellan, Carlos, Kim, Sally Yunsun, Gaboriau, David C. A., Hind, Matthew, del Río Hernández, Armando E., Griffiths, Mark, Dean, Charlotte H.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Cell and Developmental Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7658195/
https://ncbi.nlm.nih.gov/pubmed/33195213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2020.577201
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