Deficiency of the Planar Cell Polarity Protein Vangl2 in Podocytes Affects Glomerular Morphogenesis and Increases Susceptibility to Injury

The planar cell polarity (PCP) signaling pathway is crucial for tissue morphogenesis. Van Gogh-like protein 2 (Vangl2) is central in the PCP pathway; in mice, Vangl2 loss is embryonically lethal because of neural tube defects, and mutations in Vangl2 are associated with human neural tube defects. In...

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Publicat a:J Am Soc Nephrol
Autors principals: Rocque, Brittany L., Babayeva, Sima, Li, Jane, Leung, Vicki, Nezvitsky, Lisa, Cybulsky, Andrey V., Gros, Philippe, Torban, Elena
Format: Artigo
Idioma:Inglês
Publicat: American Society of Nephrology 2015
Matèries:
Basic Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4341486/
https://ncbi.nlm.nih.gov/pubmed/25145929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2014040340
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