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In vitro selection of ribozyme ligases that use prebiotically plausible 2-aminoimidazole–activated substrates

The hypothesized central role of RNA in the origin of life suggests that RNA propagation predated the advent of complex protein enzymes. A critical step of RNA replication is the template-directed synthesis of a complementary strand. Two experimental approaches have been extensively explored in the...

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Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Walton, Travis, DasGupta, Saurja, Duzdevich, Daniel, Oh, Seung Soo, Szostak, Jack W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2020
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7084097/
https://ncbi.nlm.nih.gov/pubmed/32123094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1914367117
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