Prebiotically Plausible “Patching” of RNA Backbone Cleavage through a 3′–5′ Pyrophosphate Linkage

[Image: see text] Achieving multiple cycles of RNA replication within a model protocell would be a critical step toward demonstrating a path from prebiotic chemistry to cellular biology. Any model for early life based on an “RNA world” must account for RNA strand cleavage and hydrolysis, which would...

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Detalhes bibliográficos
Publicado no:J Am Chem Soc
Main Authors: Wright, Tom H., Giurgiu, Constantin, Zhang, Wen, Radakovic, Aleksandar, O’Flaherty, Derek K., Zhou, Lijun, Szostak, Jack W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2019
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7577263/
https://ncbi.nlm.nih.gov/pubmed/31651170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.9b08237
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