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Inosine, but none of the 8-oxo-purines, is a plausible component of a primordial version of RNA

The emergence of primordial RNA-based life would have required the abiotic synthesis of nucleotides, and their participation in nonenzymatic RNA replication. Although considerable progress has been made toward potentially prebiotic syntheses of the pyrimidine nucleotides (C and U) and their 2-thio v...

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Bibliografiska uppgifter
I publikationen:Proc Natl Acad Sci U S A
Huvudupphovsmän: Kim, Seohyun Chris, O’Flaherty, Derek K., Zhou, Lijun, Lelyveld, Victor S., Szostak, Jack W.
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2018
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6310819/
https://ncbi.nlm.nih.gov/pubmed/30509978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1814367115
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