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Nonenzymatic Template-Directed Synthesis of Mixed-Sequence 3′-NP-DNA up to 25 Nucleotides Long Inside Model Protocells

[Image: see text] Efficiently copying mixed-sequence oligonucleotide templates nonenzymatically is a long-standing problem both with respect to the origin of life, and with regard to bottom up efforts to synthesize artificial living systems. Here we report an efficient and sequence-general nonenzyma...

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Publicado en:J Am Chem Soc
Autores principales: O’Flaherty, Derek K., Zhou, Lijun, Szostak, Jack W.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Chemical Society 2019
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7547854/
https://ncbi.nlm.nih.gov/pubmed/31180644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.9b04858
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