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Structural basis of human KCNQ1 modulation and gating

KCNQ1, also known as Kv7.1, is a voltage-dependent K(+) channel that regulates gastric acid secretion, salt and glucose homeostasis and heart rhythm. Its functional properties are regulated in a tissue-specific manner through co-assembly with beta subunits KCNE1-5. In non-excitable cells KCNQ1 forms...

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Detalhes bibliográficos
Publicado no:Cell
Main Authors: Sun, Ji, MacKinnon, Roderick
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7083075/
https://ncbi.nlm.nih.gov/pubmed/31883792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2019.12.003
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