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Structure of the voltage-gated K(+) channel Eag1 reveals an alternative voltage sensing mechanism
Voltage-gated potassium channels (K(v)) are gated by the movement of the transmembrane voltage sensor, which is coupled, through the helical S4–S5 linker, to the potassium pore. We determined the single-particle cryo-EM structure of mammalian K(v)10.1 or Eag1, bound to the channel inhibitor calmodul...
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| Yayımlandı: | Science |
|---|---|
| Asıl Yazarlar: | , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
2016
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5477842/ https://ncbi.nlm.nih.gov/pubmed/27516594 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aaf8070 |
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