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Voltage-dependent K(+) channel gating and voltage sensor toxin sensitivity depend on the mechanical state of the lipid membrane

Voltage-dependent K(+) (Kv) channels underlie action potentials through gating conformational changes that are driven by membrane voltage. In this study of the paddle chimera Kv channel, we demonstrate that the rate of channel opening, the voltage dependence of the open probability, and the maximum...

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Detalhes bibliográficos
Main Authors: Schmidt, Daniel, MacKinnon, Roderick
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2614752/
https://ncbi.nlm.nih.gov/pubmed/19050073
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0810187105
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