Sirt6 opposes glycochenodeoxycholate-induced apoptosis of biliary epithelial cells through the AMPK/PGC-1α pathway

BACKGROUND: Induction of biliary epithelial cell apoptosis by toxic bile acids is involved in the development of cholestatic disease, but the underlying molecular mechanism is not clear. The purpose of this study was to investigate the molecular mechanisms involved in Sirt6 protection against the ap...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:Cell Biosci
Autori principali: Li, Jiye, Yu, Dongsheng, Chen, Sanyang, Liu, Yifan, Shi, Jihua, Zhang, Jiakai, Wen, Peihao, Wang, Zhihui, Li, Jie, Guo, Wenzhi, Zhang, Shuijun
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2020
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7083051/
https://ncbi.nlm.nih.gov/pubmed/32206298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13578-020-00402-6
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