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Sirt6 opposes glycochenodeoxycholate-induced apoptosis of biliary epithelial cells through the AMPK/PGC-1α pathway

BACKGROUND: Induction of biliary epithelial cell apoptosis by toxic bile acids is involved in the development of cholestatic disease, but the underlying molecular mechanism is not clear. The purpose of this study was to investigate the molecular mechanisms involved in Sirt6 protection against the ap...

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發表在:Cell Biosci
Main Authors: Li, Jiye, Yu, Dongsheng, Chen, Sanyang, Liu, Yifan, Shi, Jihua, Zhang, Jiakai, Wen, Peihao, Wang, Zhihui, Li, Jie, Guo, Wenzhi, Zhang, Shuijun
格式: Artigo
語言:Inglês
出版: BioMed Central 2020
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7083051/
https://ncbi.nlm.nih.gov/pubmed/32206298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13578-020-00402-6
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