Sirt6 opposes glycochenodeoxycholate-induced apoptosis of biliary epithelial cells through the AMPK/PGC-1α pathway

BACKGROUND: Induction of biliary epithelial cell apoptosis by toxic bile acids is involved in the development of cholestatic disease, but the underlying molecular mechanism is not clear. The purpose of this study was to investigate the molecular mechanisms involved in Sirt6 protection against the ap...

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Bibliographic Details
Published in:Cell Biosci
Main Authors: Li, Jiye, Yu, Dongsheng, Chen, Sanyang, Liu, Yifan, Shi, Jihua, Zhang, Jiakai, Wen, Peihao, Wang, Zhihui, Li, Jie, Guo, Wenzhi, Zhang, Shuijun
Format: Artigo
Language:Inglês
Published: BioMed Central 2020
Subjects:
Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7083051/
https://ncbi.nlm.nih.gov/pubmed/32206298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13578-020-00402-6
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