Targeting BET Proteins With a PROTAC Molecule Elicits Potent Anticancer Activity in HCC Cells

Background and Aim: Bromodomain and extraterminal domain (BET) family proteins are epigenetic regulators involved in human malignances. Targeting BET proteins for degradation using proteolysis-targeting chimera (PROTAC) recently has drawn increasing attention in the field of cancer therapeutics. BET...

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Gepubliceerd in:Front Oncol
Hoofdauteurs: Zhang, Huapeng, Li, Gongquan, Zhang, Yi, Shi, Jihua, Yan, Bing, Tang, Hongwei, Chen, Sanyang, Zhang, Jiakai, Wen, Peihao, Wang, Zhihui, Pang, Chun, Li, Jie, Guo, Wenzhi, Zhang, Shuijun
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Frontiers Media S.A. 2020
Onderwerpen:
Oncology
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6971110/
https://ncbi.nlm.nih.gov/pubmed/31993368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2019.01471
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