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Discovery of PROTAC BCL-X(L) Degraders as Potent Anticancer Agents with Low On-target Platelet Toxicity

Anti-apoptotic protein BCL-X(L) plays a key role in tumorigenesis and cancer chemotherapy resistance, rendering it an attractive target for cancer treatment. However, BCL-X(L) inhibitors such as ABT-263 cannot be safely used in the clinic because platelets solely depend on BCL-X(L) to maintain their...

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Detalhes bibliográficos
Publicado no:Eur J Med Chem
Main Authors: Zhang, Xuan, Thummuri, Dinesh, Liu, Xingui, Hu, Wanyi, Zhang, Peiyi, Khan, Sajid, Yuan, Yaxia, Zhou, Daohong, Zheng, Guangrong
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7433031/
https://ncbi.nlm.nih.gov/pubmed/32145645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2020.112186
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