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Discovery of PROTAC BCL-X(L) Degraders as Potent Anticancer Agents with Low On-target Platelet Toxicity
Anti-apoptotic protein BCL-X(L) plays a key role in tumorigenesis and cancer chemotherapy resistance, rendering it an attractive target for cancer treatment. However, BCL-X(L) inhibitors such as ABT-263 cannot be safely used in the clinic because platelets solely depend on BCL-X(L) to maintain their...
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| Publicado no: | Eur J Med Chem |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7433031/ https://ncbi.nlm.nih.gov/pubmed/32145645 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2020.112186 |
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