Therapeutic inhibition of mTORC2 rescues the behavioral and neurophysiological abnormalities associated with Pten-deficiency.

Dysregulation of the mammalian target of rapamycin (mTOR) signaling, which is mediated by two structurally and functionally distinct complexes mTORC1 and mTORC2, has been implicated in several neurological disorders(1-3). Individuals carrying loss-of-function mutations in the phosphatase and tensin...

Full description

Saved in:
Bibliographic Details
Published in:Nat Med
Main Authors: Chen, Chien-Ju, Sgritta, Martina, Mays, Jacqunae, Zhou, Hongyi, Lucero, Rocco, Park, Jin, Wang, I-Ching, Park, Jun Hyoung, Kaipparettu, Benny Abraham, Stoica, Loredana, Nejad, Paymaan Jafar, Rigo, Frank, Chin, Jeannie, Noebels, Jeffrey L., Costa-Mattioli, Mauro
Format: Artigo
Language:Inglês
Published: 2019
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7082835/
https://ncbi.nlm.nih.gov/pubmed/31636454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41591-019-0608-y
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items