Therapeutic inhibition of mTORC2 rescues the behavioral and neurophysiological abnormalities associated with Pten-deficiency.

Dysregulation of the mammalian target of rapamycin (mTOR) signaling, which is mediated by two structurally and functionally distinct complexes mTORC1 and mTORC2, has been implicated in several neurological disorders(1-3). Individuals carrying loss-of-function mutations in the phosphatase and tensin...

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Publicado no:Nat Med
Main Authors: Chen, Chien-Ju, Sgritta, Martina, Mays, Jacqunae, Zhou, Hongyi, Lucero, Rocco, Park, Jin, Wang, I-Ching, Park, Jun Hyoung, Kaipparettu, Benny Abraham, Stoica, Loredana, Nejad, Paymaan Jafar, Rigo, Frank, Chin, Jeannie, Noebels, Jeffrey L., Costa-Mattioli, Mauro
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7082835/
https://ncbi.nlm.nih.gov/pubmed/31636454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41591-019-0608-y
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