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mTORC2, but not mTORC1, is required for hippocampal mGluR-LTD and associated behaviors

The mechanistic target of rapamycin complex 1 (mTORC1) has been reported to be necessary for metabotropic glutamate receptor-mediated long-term depression (mGluR-LTD). Here we found that mTORC1-deficient mice exhibit normal hippocampal mGluR-LTD and associated behaviors. Moreover, rapamycin blocks m...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nat Neurosci
Prif Awduron: Zhu, Ping Jun, Chen, Chien-Ju, Mays, Jacqunae, Stoica, Loredana, Costa-Mattioli, Mauro
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2018
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6467217/
https://ncbi.nlm.nih.gov/pubmed/29786082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41593-018-0156-7
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