Selective pharmacogenetic inhibition of mammalian target of Rapamycin complex I (mTORC1) blocks long-term synaptic plasticity and memory storage

Both the formation of long-term memory (LTM) and late-long-term potentiation (L-LTP), which is thought to represent the cellular model of learning and memory, require de novo protein synthesis. The mammalian target of Rapamycin (mTOR) complex I (mTORC1) integrates information from various synaptic i...

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Main Authors: Stoica, Loredana, Zhu, Ping Jun, Huang, Wei, Zhou, Hongyi, Kozma, Sara C., Costa-Mattioli, Mauro
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2011
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3048125/
https://ncbi.nlm.nih.gov/pubmed/21307309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1014715108
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