Structural basis for pharmacological modulation of the TRPC6 channel

Transient receptor potential canonical (TRPC) proteins form nonselective cation channels that play physiological roles in a wide variety of cells. Despite growing evidence supporting the therapeutic potential of TRPC6 inhibition in treating pathological cardiac and renal conditions, mechanistic unde...

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Veröffentlicht in:eLife
Hauptverfasser: Bai, Yonghong, Yu, Xinchao, Chen, Hao, Horne, Daniel, White, Ryan, Wu, Xiaosu, Lee, Paul, Gu, Yan, Ghimire-Rijal, Sudipa, Lin, Daniel C-H, Huang, Xin
Format: Artigo
Sprache:Inglês
Veröffentlicht: eLife Sciences Publications, Ltd 2020
Schlagworte:
Structural Biology and Molecular Biophysics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7082128/
https://ncbi.nlm.nih.gov/pubmed/32149605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.53311
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