HIV-1 Vpu Downregulates Tim-3 from the Surface of Infected CD4(+) T Cells

Along with other immune checkpoints, T cell immunoglobulin and mucin domain-containing protein 3 (Tim-3) is expressed on exhausted CD4(+) and CD8(+) T cells and is upregulated on the surface of these cells upon infection by human immunodeficiency virus type 1 (HIV-1). Recent reports have suggested a...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Prévost, Jérémie, Edgar, Cassandra R., Richard, Jonathan, Trothen, Steven M., Jacob, Rajesh Abraham, Mumby, Mitchell J., Pickering, Suzanne, Dubé, Mathieu, Kaufmann, Daniel E., Kirchhoff, Frank, Neil, Stuart J. D., Finzi, Andrés, Dikeakos, Jimmy D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2020
Assuntos:
Virus-Cell Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7081912/
https://ncbi.nlm.nih.gov/pubmed/31941771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01999-19
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