HIV-1 Vpu Downregulates Tim-3 from the Surface of Infected CD4(+) T Cells

Along with other immune checkpoints, T cell immunoglobulin and mucin domain-containing protein 3 (Tim-3) is expressed on exhausted CD4(+) and CD8(+) T cells and is upregulated on the surface of these cells upon infection by human immunodeficiency virus type 1 (HIV-1). Recent reports have suggested a...

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Vydáno v:J Virol
Hlavní autoři: Prévost, Jérémie, Edgar, Cassandra R., Richard, Jonathan, Trothen, Steven M., Jacob, Rajesh Abraham, Mumby, Mitchell J., Pickering, Suzanne, Dubé, Mathieu, Kaufmann, Daniel E., Kirchhoff, Frank, Neil, Stuart J. D., Finzi, Andrés, Dikeakos, Jimmy D.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2020
Témata:
Virus-Cell Interactions
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7081912/
https://ncbi.nlm.nih.gov/pubmed/31941771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01999-19
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