HIV-1 Vpu Mediates HLA-C Downregulation

Many pathogens evade cytotoxic T lymphocytes (CTLs) by downregulating HLA molecules on infected cells, but the loss of HLA can trigger NK cell-mediated lysis. HIV-1 is thought to subvert CTLs while preserving NK cell inhibition by Nef-mediated downregulation of HLA-A and -B but not HLA-C molecules....

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Publicado no:Cell Host Microbe
Main Authors: Apps, Richard, Del Prete, Gregory Q., Chatterjee, Pramita, Lara, Abigail, Brumme, Zabrina L., Brockman, Mark A., Neil, Stuart, Pickering, Suzanne, Schneider, Douglas K., Piechocka-Trocha, Alicja, Walker, Bruce D., Thomas, Rasmi, Shaw, George M., Hahn, Beatrice H., Keele, Brandon F., Lifson, Jeffrey D., Carrington, Mary
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4904791/
https://ncbi.nlm.nih.gov/pubmed/27173934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2016.04.005
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