HLA-C downregulation by HIV-1 adapts to host HLA genotype

HIV-1 can downregulate HLA-C on infected cells, using the viral protein Vpu, and the magnitude of this downregulation varies widely between primary HIV-1 variants. The selection pressures that result in viral downregulation of HLA-C in some individuals, but preservation of surface HLA-C in others ar...

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Bachtel, Nathaniel D., Umviligihozo, Gisele, Pickering, Suzanne, Mota, Talia M., Liang, Hua, Del Prete, Gregory Q., Chatterjee, Pramita, Lee, Guinevere Q., Thomas, Rasmi, Brockman, Mark A., Neil, Stuart, Carrington, Mary, Bwana, Bosco, Bangsberg, David R., Martin, Jeffrey N., Kallas, Esper G., Donini, Camila S., Cerqueira, Natalia B., O’Doherty, Una T., Hahn, Beatrice H., Jones, R. Brad, Brumme, Zabrina L., Nixon, Douglas F., Apps, Richard
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6138419/
https://ncbi.nlm.nih.gov/pubmed/30180214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1007257
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