Upregulation of BST-2 by Type I Interferons Reduces the Capacity of Vpu To Protect HIV-1-Infected Cells from NK Cell Responses

The HIV-1 accessory protein Vpu enhances viral release by counteracting the restriction factor BST-2. Furthermore, Vpu promotes NK cell evasion by downmodulating cell surface NTB-A and PVR, known ligands of the NK cell receptors NTB-A and DNAM-1, respectively. While it has been established that Vpu’...

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Publicado en:mBio
Main Authors: Prévost, Jérémie, Pickering, Suzanne, Mumby, Mitchell J., Medjahed, Halima, Gendron-Lepage, Gabrielle, Delgado, Gloria G., Dirk, Brennan S., Dikeakos, Jimmy D., Stürzel, Christina M., Sauter, Daniel, Kirchhoff, Frank, Bibollet-Ruche, Frederic, Hahn, Beatrice H., Dubé, Mathieu, Kaufmann, Daniel E., Neil, Stuart J. D., Finzi, Andrés, Richard, Jonathan
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2019
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6581860/
https://ncbi.nlm.nih.gov/pubmed/31213558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.01113-19
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