Identification and Screening of Selective WEE2 Inhibitors to Develop Non-Hormonal Contraceptives that Specifically Target Meiosis

We used a progressive elimination strategy to identify oocyte-specific WEE2 kinase inhibitors for potential non-hormonal contraceptives that target meiosis. Beginning with an in-house library of over 300,000 compounds, virtual high throughput screening identified 57 WEE2 inhibitors with preferential...

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Publicado en:ChemistrySelect
Main Authors: Hanna, Carol B., Yao, Shan, Martin, Mat, Schönbrunn, Ernst, Georg, Gunda I., Jensen, Jeffrey T., Cuellar, Rebecca A. D.
Formato: Artigo
Idioma:Inglês
Publicado: 2019
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7079731/
https://ncbi.nlm.nih.gov/pubmed/32190728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/slct.201903696
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