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Development of WEE2 kinase inhibitors as novel non-hormonal female contraceptives that target meiosis

WEE2 oocyte meiosis inhibiting kinase is a well-conserved oocyte specific kinase with a dual regulatory role during meiosis. Active WEE2 maintains immature, germinal vesicle stage oocytes in prophase I arrest prior to the luteinizing hormone surge and facilitates exit from metaphase II arrest at fer...

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Detalhes bibliográficos
Publicado no:Biol Reprod
Main Authors: Hanna, Carol B, Mudaliar, Deepti, John, Kristen, Allen, C Leigh, Sun, Luxin, Hawkinson, Jon E, Schönbrunn, Ernst, Georg, Gunda I, Jensen, Jeffrey T
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7401407/
https://ncbi.nlm.nih.gov/pubmed/32667031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/biolre/ioaa097
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