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Development of WEE2 kinase inhibitors as novel non-hormonal female contraceptives that target meiosis
WEE2 oocyte meiosis inhibiting kinase is a well-conserved oocyte specific kinase with a dual regulatory role during meiosis. Active WEE2 maintains immature, germinal vesicle stage oocytes in prophase I arrest prior to the luteinizing hormone surge and facilitates exit from metaphase II arrest at fer...
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| Gepubliceerd in: | Biol Reprod |
|---|---|
| Hoofdauteurs: | , , , , , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Oxford University Press
2020
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7401407/ https://ncbi.nlm.nih.gov/pubmed/32667031 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/biolre/ioaa097 |
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