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Gating mechanism of hyperpolarization-activated HCN pacemaker channels

Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are essential for rhythmic activity in the heart and brain, and mutations in HCN channels are linked to heart arrhythmia and epilepsy. HCN channels belong to the family of voltage-gated K(+) (Kv) channels. However, why HCN channels a...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Ramentol, Rosamary, Perez, Marta E., Larsson, H. Peter
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7078272/
https://ncbi.nlm.nih.gov/pubmed/32184399
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-15233-9
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