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Insights into the molecular mechanism for hyperpolarization-dependent activation of HCN channels

Hyperpolarization-activated, cyclic nucleotide-gated (HCN) ion channels are both voltage- and ligand-activated membrane proteins that contribute to electrical excitability and pace-making activity in cardiac and neuronal cells. These channels are members of the voltage-gated Kv channel superfamily a...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Flynn, Galen E., Zagotta, William N.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6112743/
https://ncbi.nlm.nih.gov/pubmed/30076228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1805596115
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