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Galectin 3–binding protein suppresses amyloid-β production by modulating β-cleavage of amyloid precursor protein
Alzheimer's disease (AD) is the most common type of dementia, and its pathogenesis is associated with accumulation of β-amyloid (Aβ) peptides. Aβ is produced from amyloid precursor protein (APP) that is sequentially cleaved by β- and γ-secretases. Therefore, APP processing has been a target in...
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| Publicado en: | J Biol Chem |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2020
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7076203/ https://ncbi.nlm.nih.gov/pubmed/31996371 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.008703 |
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