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eIF1 discriminates against suboptimal initiation sites to prevent excessive uORF translation genome-wide
The translation preinitiation complex (PIC) scans the mRNA for an AUG codon in a favorable context. Previous findings suggest that the factor eIF1 discriminates against non-AUG start codons by impeding full accommodation of Met-tRNA(i) in the P site of the 40S ribosomal subunit, necessitating eIF1 d...
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| Veröffentlicht in: | RNA |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Cold Spring Harbor Laboratory Press
2020
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7075259/ https://ncbi.nlm.nih.gov/pubmed/31915290 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.073536.119 |
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