C/EBPβ(ΔuORF) mice—a genetic model for uORF-mediated translational control in mammals

Upstream ORFs (uORFs) are translational control elements found predominantly in transcripts of key regulatory genes. No mammalian genetic model exists to experimentally validate the physiological relevance of uORF-regulated translation initiation. We report that mice deficient for the CCAAT/enhancer...

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Bibliografske podrobnosti
Main Authors: Wethmar, Klaus, Bégay, Valérie, Smink, Jeske J., Zaragoza, Katrin, Wiesenthal, Volker, Dörken, Bernd, Calkhoven, Cornelis F., Leutz, Achim
Format: Artigo
Jezik:Inglês
Izdano: Cold Spring Harbor Laboratory Press 2010
Teme:
Research Communication
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2802187/
https://ncbi.nlm.nih.gov/pubmed/20047998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.557910
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