C/EBPβ(ΔuORF) mice—a genetic model for uORF-mediated translational control in mammals

Upstream ORFs (uORFs) are translational control elements found predominantly in transcripts of key regulatory genes. No mammalian genetic model exists to experimentally validate the physiological relevance of uORF-regulated translation initiation. We report that mice deficient for the CCAAT/enhancer...

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Detalhes bibliográficos
Main Authors: Wethmar, Klaus, Bégay, Valérie, Smink, Jeske J., Zaragoza, Katrin, Wiesenthal, Volker, Dörken, Bernd, Calkhoven, Cornelis F., Leutz, Achim
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2010
Assuntos:
Research Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2802187/
https://ncbi.nlm.nih.gov/pubmed/20047998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.557910
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