C/EBPβ(ΔuORF) mice—a genetic model for uORF-mediated translational control in mammals

Upstream ORFs (uORFs) are translational control elements found predominantly in transcripts of key regulatory genes. No mammalian genetic model exists to experimentally validate the physiological relevance of uORF-regulated translation initiation. We report that mice deficient for the CCAAT/enhancer...

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Main Authors: Wethmar, Klaus, Bégay, Valérie, Smink, Jeske J., Zaragoza, Katrin, Wiesenthal, Volker, Dörken, Bernd, Calkhoven, Cornelis F., Leutz, Achim
格式: Artigo
語言:Inglês
出版: Cold Spring Harbor Laboratory Press 2010
主題:
Research Communication
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2802187/
https://ncbi.nlm.nih.gov/pubmed/20047998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.557910
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