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Determinants of genome-wide distribution and evolution of uORFs in eukaryotes

Upstream open reading frames (uORFs) play widespread regulatory functions in modulating mRNA translation in eukaryotes, but the principles underlying the genomic distribution and evolution of uORFs remain poorly understood. Here, we analyze ~17 million putative canonical uORFs in 478 eukaryotic spec...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Zhang, Hong, Wang, Yirong, Wu, Xinkai, Tang, Xiaolu, Wu, Changcheng, Lu, Jian
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7889888/
https://ncbi.nlm.nih.gov/pubmed/33597535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-21394-y
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