Determinants of genome-wide distribution and evolution of uORFs in eukaryotes

Upstream open reading frames (uORFs) play widespread regulatory functions in modulating mRNA translation in eukaryotes, but the principles underlying the genomic distribution and evolution of uORFs remain poorly understood. Here, we analyze ~17 million putative canonical uORFs in 478 eukaryotic spec...

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Udgivet i:Nat Commun
Main Authors: Zhang, Hong, Wang, Yirong, Wu, Xinkai, Tang, Xiaolu, Wu, Changcheng, Lu, Jian
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7889888/
https://ncbi.nlm.nih.gov/pubmed/33597535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-21394-y
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