Genome-wide maps of ribosomal occupancy provide insights into adaptive evolution and regulatory roles of uORFs during Drosophila development

Upstream open reading frames (uORFs) play important roles in regulating the main coding DNA sequences (CDSs) via translational repression. Despite their prevalence in the genomes, uORFs are overall discriminated against by natural selection. However, it remains unclear why in the genomes there are s...

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Bibliographic Details
Published in:PLoS Biol
Main Authors: Zhang, Hong, Dou, Shengqian, He, Feng, Luo, Junjie, Wei, Liping, Lu, Jian
Format: Artigo
Language:Inglês
Published: Public Library of Science 2018
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6070289/
https://ncbi.nlm.nih.gov/pubmed/30028832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.2003903
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