Genome-wide search for novel human uORFs and N-terminal protein extensions using ribosomal footprinting

So far, the annotation of translation initiation sites (TISs) has been based mostly upon bioinformatics rather than experimental evidence. We adapted ribosomal footprinting to puromycin-treated cells to generate a transcriptome-wide map of TISs in a human monocytic cell line. A neural network was tr...

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Detalhes bibliográficos
Main Authors: Fritsch, Claudia, Herrmann, Alexander, Nothnagel, Michael, Szafranski, Karol, Huse, Klaus, Schumann, Frank, Schreiber, Stefan, Platzer, Matthias, Krawczak, Michael, Hampe, Jochen, Brosch, Mario
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2012
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3483550/
https://ncbi.nlm.nih.gov/pubmed/22879431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.139568.112
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