eIF1 modulates the recognition of suboptimal translation initiation sites and steers gene expression via uORFs

Alternative translation initiation mechanisms such as leaky scanning and reinitiation potentiate the polycistronic nature of human transcripts. By allowing for reprogrammed translation, these mechanisms can mediate biological responses to stimuli. We combined proteomics with ribosome profiling and m...

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Bibliografski detalji
Izdano u:Nucleic Acids Res
Glavni autori: Fijałkowska, Daria, Verbruggen, Steven, Ndah, Elvis, Jonckheere, Veronique, Menschaert, Gerben, Van Damme, Petra
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2017
Teme:
RNA
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5570006/
https://ncbi.nlm.nih.gov/pubmed/28541577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx469
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